Background

1. Dean, School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China, 2024-

2. Vice Dean, School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China, 2021-2024

3. Professor, Department of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China, 2018-

4. Associate Professor, Department of Pharmaceutical Sciences, Tianjin Medical University, Tianjin, China, 2013-2017

5. Postdoctoral Fellow, Tianjin University, Tianjin, China, 2013

6. Postdoctoral Fellow, Max Planck Institute of Biophysics, Frankfurt, German, 2012

7. Postdoctoral Fellow, University of Michigan, Ann Arbor, USA, 2011

8. Ph.D. Tianjin University & University of Michigan, 2010

9. B.S. Tianjin University, Tianjin, China, 2005

Honors & Awards

1. National Talent Project Young Scholars, 2023

2. 2023 Elsevier China Gold Top OA Author Award, 2023

3. Tianjin Natural Science Third Prize,2023

4. Excellent Youth Editorial Board Member of Asian Journal of Pharmaceutical Sciences, 2023

5. Tianjin Youth Science and Technology Work Association "Outstanding Young Science and Technology Workers", 2021

6. 2021 International Nanomedicine Conference "Outstanding Young Scholar Report Award", 2021

7. Tianjin Colleges and Universities "Young and Middle-Aged Backbone Innovative Talent Training Program", 2019

8. Tianjin Innovative Talent Promotion Plan "Young and Middle-Aged Scientific and Technological Innovation Leaders", 2019

9. Tianjin Talent Development Special Support Program "Youth Top Talent", 2019

10. Tianjin "Young Talent Lifting Project", 2018

11. First Level Candidates of 131 Innovative Talents Training Project, 2018

Other Roles

1. Youth Committee of Chinese Society of Biomedical Engineering, Nanomedicine and Engineering Branch

2. Youth Committee of Pharmaceutical Committee of Chinese Pharmaceutical Society

3. Young Editor of “Asian Journal of Pharmaceutical Sciences” (AJPS, IF 10.2)

4. Young Committee of The Nanomedicine and Engineering Branch of The Chinese Society of Biomedical Engineering

5. Member of The Chinese American Society of Nanomedicine and Nanobiotechnology

6. Member of Tianjin Medical Imaging Technology Research Association

7. Member of Tianjin Society of Biomedical Engineering

Publications

1. Weiran Cao, Xue Zhang, Yaxuan Feng, Rui Li, An Lu, Zijie Li, Fei Yu, Lu Sun, Jancheng Wang, Zhiyu Wang, Huining He*. Lipid Nanoparticular Codelivery System for Enhanced Antitumor Effects by Ferroptosis-Apoptosis Synergistic with Programmed Cell Death-Ligand 1 Downregulation. ACS Nano, 2024, Online. (IF: 17.1,一区)

2. Weiran Cao, Xue Zhang, Rui Li, Zijie Li, An Lu, Fei Yu*, Lu Sun, Jiancheng Wang*, Zhiyu Wang*, Huining He*. Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment. Journal of Controlled Release, 2024, 368:52-65. (IF: 11.467, 一区)

3. Sunhui Chen¹, Qiujun Qiu¹, Dongdong Wang, Dejun She, Bo Yin, Guolong Gu, Meihong Chai, Dong Nyoung Heo, Huining He*, Jianxin Wang*. Dual-sensitive drug-loaded hydrogel system for local inhibition of post-surgical glioma recurrence. Journal of Controlled Release, 2022 ,9;349:565-579. (IF: 11.467,一区)

4. Xing Pei¹, Jiyoung Shin¹, Heejung Kim¹, Nana Wang, Miyun Yoon, Xiongwen Chen, Jianqing Gao, Huining He*, Seungjin Lee*. Cardiac-derived stem cell engineered with constitutively active HIF-1α gene enhancesblood perfusion of hindlimb ischemia. Journal of Industrial and Engineering Chemistry, 105:210, 2022. (IF: 6.76, 二区)

5. Weiran Cao¹, Rui Li¹, Xing Pei, Meihong Chai, Lu Sun, Yuanyu Huang, Jiancheng Wang, Stefan Barth, Fei Yu*, Huining He*. Antibody-siRNA Conjugates (ARC): Emerging siRNA Drug Formulation. Medicine in Drug Discovery, 15:100128, 2022. (New Journal)

6. Xing Pei, Xiaojuan Zhang, Lu Zhang, Mengmeng Yuan, Lu Sun, Fei Yu, Bangmao Wang, Jingwen Zhao* , Huining He* ,Victor C. Yang. Targeted exosomes for co-delivery of siFGL1 and siTGF-β1trigger combined cancer immunotherapy by remodeling immunosuppressive tumormicroenvironment. Chemical Engineering Journal, 421:129774, 2021. (IF: 16.744, 一区)

7. Zhili Yu¹, Xiaojuan Zhang¹, Xing Pei¹, Weiran Cao, Junxiao Ye, Jianxin Wang ,Lu Sun, Fei Yu, Jiancheng Wang, Nan Li, Kyuri Lee, Stefan Barth, Victor C.Yang, Huining He*. Antibody-siRNA conjugates (ARCs) using multifunctional peptide as a tumor enzyme cleavable linker mediated effective intracellular delivery of siRNA. International Journal of Pharmaceutics, 606(1):120940, 2021. (IF: 6.51, 二区)

8. Sunhui Chen, Qiujun Qiu , Dongdong Wang, Dejun She , Bo Yin, Meihong Chai, Huining He*, Dong Nyoung Heo, Jianxin Wang*. Long acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection. Frontiers of Chemical Science and Engineering, 1-10, 2021. (IF: 4.803, 二区)

9. You Xu¹ , Xiaojuan Zhang¹ , Nana Wang, Xing Pei, Yiyue Guo, Jianxin Wang, Stefan Barth, Fei Yu, Seung Jin Lee, Huining He*, Victor C. Yang. Cell Penetrating Peptide Enhanced Insulin Buccal Absorption. International Journal of Pharmaceutics, 584:119469, 2020. (IF:6.51, 二区)

10. Xing Pei¹ , Heejung Kim¹ , Minjoo Lee, Nana Wang, Jiyoung Shin, Seungjin Lee*, Miyun Yoon, Victor C. Yang, Huining He*. Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model. Journal of Controlled Release, 322:610–621, 2020. (IF: 11.467, 一区)

11. Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He*, Lu Sun*. MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging. Biomaterials Science, 8(8):2308, 2020. (IF: 7.59, 二区)

12. Hui Cui, Bowen Zhang, Haolin Ding, Youming Hu, Xianhua Wang, Liang Xu, Xiaojie Jiao, Huining He*, Xu Wang*, Xianshun Zeng, Victor C. Yang. A cis-diol/pH Dual-Responsive Upconversion Nanoplatform: Synthesis, Characterization, and in vitro Demonstration. Journal of Biomedical Nanotechnology, 2019, 15(3):487-499. (IF:3.641, 四区)

Grants

1. Achievement Transformation Project, 24021YS002, (PI, ¥14,600,000) “Preparation and application of a highly effective siRNA co-delivery system targeting glioma initiation cells”, 2024.01-2029.01

2. 2024.01-2029.01, Achievement Transformation Project, 24011YY117, (PI, ¥10,000,000) “Development of targeted peptide-nucleic acid couplings in skin and hair”

3. 2022.01-2025.12, National Natural Science Foundation of China,8217131811, (PI, ¥530,000)“Study on multifunctional exosome-thermosensitive gel in situ drug delivery system for inhibiting post-surgical glioma recurrence”

4. 2021.07- 2023.06, National Key Research and Development Plan, 2021YFE0106900 , (PI, ¥1400,000)“Targeted delivery of siRNAs using SNAP tag based antibody format for precision immunotherapy of specific subsets of Leukemia”

5. 2020.11-2023.10, The Beijing-Tianjin-Hebei Basic Research Cooperation Project,20J00216 , (PI, ¥600,000)“The combinaton effects of chemotherapy and immunotherapy on esophageal cancer by precision drug delivery system” Natural Science Foundation of China:

6. 2016.12-2019.11, National Key Research and Development Plan, 2016YFE0119200, (PI, ¥960,000)“Research on development of key biotherapeutics delivery strategies and cardiac stem cell tissue engineering for regenerative treatment of Limb Ischemia”

7. 2015.01-2017.12, National Natural Science Foundation of China, 81402856, (PI, ¥230,000)“Research on tomor-targeted and site-specific activated prodrug type macromolecular drug delivery system for colon cancer therapy”

8. 2015.04-2018.03, Tianjin Research Program of Application Foundation and Advanced Technology,15JCYBJC28700, (PI, ¥100,000) “Research on key technologies on gene therapy of colon cancer using enzyme sensitive and targeting systems”