Background

1.Professor, Department of Pharmaceutics, Tianjin Medical University, Tianjin, China, 2015

2.Associate Professor, Department of Pharmaceutics, Tianjin Medical University, Tianjin, China, 2011-2015

3.Lecturer, Department of Pharmaceutics, Tianjin Medical University, Tianjin, China, 2006-2010

4.Postdoctoral Fellow Tianjin Medical University, Tianjin, China, 2012

5.Ph.D. Chinese Academy of Medical Sciences & Pecking Union Medical College, Beijing, China, 2006

6.M.S. Ocean University of China, Qingdao, China, 2003

7.B.S. Shenyang Pharmaceutical University, Shenyang, China, 1997

Honors & Awards

1.1st Award, Chinese Anti-cancer Association Science and Technology Award, 2023.

2.Excellent Talent Project of Tianjin Medical University, 2020

3.Tianjin Young and Middle-Aged Backbone Innovative Talent Support Program, 2017.

4.Excellent Talent Project of Tianjin Medical University, 2016

5.2nd Award, Tianjin Science and Technology Award, 2013

6.New Century Talents of Tianjin Medical University, 2009

Other Roles

1.Committee member of Nanomedicine and Engineering Branch Committee, Chinese Society of Biomedical Engineering

2.Committee member of Society of Plant Nutrition and Health, Chinese Health Association

3.Committee member of Distance Education Branch Committee, China Association of Minority Medicine

4.Editorial board member of Cancer Biology & Medicine

Publications

1.Chen Q, Han L, Wu J, Cheng Y, Bai Y, Qian Z, Yang M, Liu X, Wang Yinsong Wang. A precise and intelligent nanomedicine for salivary adenoid cystic carcinoma treatment by combining antivascular photodynamic therapy and neuroinhibitory chemotherapy. Advanced Functional Materials, 2024, 34(13): 2312732.

2.Zhang T, Bai L, You R, Yang M, Chen Q, Cheng Y, Qian Z, Wang Yinsong*, Liu Y. Homologous-targeting biomimetic nanoparticles co-loaded with melittin and a photosensitizer for the combination therapy of triple negative breast cancer. J Mater Chem B, 2024, 12(22): 5465-5478.

3.Cheng Y, Qian Z, Liu X, Zhang Y, Chen Q, Shan T, Jiang X, Liu Y, Liu Y*, Wang Yinsong*. A NIR-II photothermal nanoplatform integrating intracellular Ca²⁺ elevation via TRPV1 activation for enhanced antitumor therapy: A powerful combination of in situ tumor vaccination and vascular disruption. Chem Eng J, 2024, 481: 148274.

4.Shi E, Shan T, Wang H, Mao L, Liang Y, Cao M, Wu Q, Li C*, Wang Y*, Wang Yinsong. A bacterial nanomedicine combines photodynamic-immunotherapy and chemotherapy for enhanced treatment of oral squamous cell carcinoma. Small, 2023, 31: e2304014.

5.Wang F, Xu L, Wen B, Song S, Zhou Y, Wu H, Wu Q, Wang Yinsong*, Tong X*, Yan H*. Ultrasound-excited temozolomide sonosensitization induces necroptosis in glioblastoma. Cancer Lett, 2023, 1: 216033.

6.Yinsong Wang. Bacterial therapy: a promising strategy for cancer immunotherapy. Cancer Biol Med, 2023, 20(11): 795-798.

7.Bai L, Shi E, Li Y, Yang M, Li C, Li C, Wang Y*, Wang Yinsong*. Oxyhemoglobin-based nanophotosensitizer for specific and synergistic photothermal and photodynamic therapies against porphyromonas gingivalis oral infection. ACS Biomater Sci Eng, 2023, 9: 485-497.

8.Cheng Y, Chen Q, Qian Z, Shan T, Bai L, Jiang X, Li C, Wang Yinsong*. Versatile red blood cells for triple-negative breast cancer treatment via stepwise photoactivations. Adv Healthcare Mater, 2023, 12: 2201690.

9.Cao M, Shi E, Wang H, Mao L, Wu Q, Li X, Liang Y, Yang X, Wang Yinsong*, Li C*. Personalized targeted therapeutic strategies against oral squamous cell carcinoma. an evidence- based review of literature. Int J Nanomedicine, 2022, 17: 4293-4306.

10.Guo Z, Xin Y, Yang L, Ran R, Wan G, Ma A, Ren H, Wang Yinsong*, Yang X*. Biomimetic nanotherapeutics based on oxygen supply and ultrasmall Cu-Se-Au alloy nanoparticles for boosting radio-photothermal ablation of breast cancer. Nano Today, 2022, 46: 101587

11.Chen B, Liu X, Li Y, Shan T, Bai L, Li C*, Wang Yinsong*. iRGD tumor-penetrating peptide-modified nano-delivery system based on a marine sulfated polysaccharide for enhanced anti-tumor efficiency against breast cancer. Int J Nanomedicine, 2022, 17: 617-633.

12. Zhang T, Liu H, Li L, Guo Z, Song J, Yang X, Wan G, Li R*, Wang Yinsong*. Leukocyte/platelet hybrid membrane- camouflaged dendritic large pore mesoporous silica nanoparticles co-loaded with photo/chemotherapeutic agents for triple negative breast cancer combination treatment. Bioact Mater, 2021, 6: 3865-3878.

13.Li Z, Pan W, Shi E, Bai L, Liu H, Li C, Wang Yinsong*, Jiayin Deng J*, Wang Y*. A multifunctional nanosystem based on bacterial cell-penetrating photosensitizer for fighting periodontitis via combining photodynamic and antibiotic therapies. ACS Biomater Sci Eng, 2021, 7: 772-786.

14.Cheng Z, Cheng Y, Chen Q, Li M, Wang J, Liu H, Li M, Ning Y, Yu Z*,Wang Yinsong*, Wang H*. Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy. Nano Today, 2020, 33: 100878.

15.Cheng Y, Chen Q, Guo Z, Li M, Yang X, Wan G*, Chen H, Zhang Q, Yinsong Wang*. An intelligent biomimetic nanoplatform for holistic treatment of metastatic triple-negative breast cancer via photothermal ablation and immune remodeling. ACS Nano, 2020, 14: 15161-15181.

16.Shi S, Wang Y, Wang B, Chen Q, Wan G, Zhang J, Zhang L, Li C*, Yinsong Wang*. Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma. Chem Eng J, 2020, 388: 124268.

17.Wan G, Cheng Y, Song J, Chen Q, Chen B, Liu Y, Ji S, Chen H*, Yinsong Wang*. Nucleus-targeting near-infrared nanoparticles based on TAT peptideconjugated IR780 for photo-chemotherapy of breast cancer. Chem Eng J, 2020, 380: 122458.

18.Gao C, Zhang Y, Zhang Y, Li S, Yang X, Chen Y, Fu J, Wang Yinsong*, Yang X*. cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent. Polym Chem, 2020, 11: 889.

Grants

1.Natural Science Foundation of China: A biomimetic photothermal nanoprobe based on TRPV1 precise activation for therapeutic research of triple-negative breast cancer (Grant Number: 82273499) 2023.01-2026.12.

2. National Natural Science Foundation of China: Multifunctional red blood cells designed based on tumor-targeted oxygen supply and high penetration for treatment of triple-negative breast cancer through combining PTT/PDT and immunotherapy (Grant Number: 81972903) 2020.01-2023.12.

3. Key Project of Natural Science Foundation of Tianjin: A biomimetic nanocarrier system mediated by mixed membrane from leukocytes and platelets for targeted treatment of triple-negative breast cancer by combining photothermal/photodynamic therapy and immunotherapy (Grant Number: 18JCZDJC33400) 2018.04-2021.03.

4. National Natural Science Foundation of China: The design of multi-functional nano-therapeutic system for combination of sonodynamic therapy, chemotherapy and immunotherapy and the study of its targeted anti-hepatoma activities (Grant Number: 81573005) 2016.01-2019.12.

5. National Natural Science Foundation of China: A dual-responsive drug delivery nanosystem for carrying and orderly releasing gene/chemotherapeutic drug and its liver-targeting anticancer effects (Grant Number: 81371671) 2014.01-2017.12.

6.National Basic Research Program of China (the 973 Program): Early diagnosis of hepatocellular carcinoma based on nanotechnology (Grant Number: 2011CB933100) 2011.01-2015.12.

7.National Natural Science Foundation of China: A pH-responsive drug delivery nanosystem for combination treatment on cancer (Grant Number: 30900303) 2010.01-2012.12.

8.Special China Postdoctoral Science Foundation: Pullulan-based pH-sensitive drug nanocarrier targeting cell nucleus for reversal of cancer drug resistance (Grant Number: 201104308) 2012.01-2014.12.

9.China Postdoctoral Science Foundation: pH-sensitive drug nanocarrier based on pullulan for overcoming cancer drug resistance. (Grant Number: 20100480654) 2011.10-2013.10.